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SERMs Steroids Nolvadex Oral Uses

Description: Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, 4-hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a selective estrogen-receptor modulator. Tamoxifen is the usual...

  • Features & Specification

    Description:

    Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, 4-hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a selective estrogen-receptor modulator. Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting.

     

    1.  Synonyms: Tamoxifen Citrate, Nolvadex, Zitazonium, Tamoxifen
    2. Molecular Formula: C26H29NO.C6H8O7
    3. Molecular weight: 563.64
    4. CAS NO.: 54965-24-1
    5. Appearance: white crystalline powder
    6. MP: 140-144 oC

     

    What This Drug Is Used For:

    Tamoxifen may be given as adjuvant therapy (treatment after successful surgery) in women or men with lymph node negative or lymph node positive breast cancer.  Cancers with positive estrogen and progesterone receptors are more likely to benefit from tamoxifen.  Tamoxifen reduces the risk of getting breast cancer in the opposite breast.

    Tamoxifen may be prescribed in metastatic (cancer that has spread) breast cancer in both women and men.

    Tamoxifen may be prescribed in women with ductal carcinoma in situ (DCIS) who have completed surgery and radiation therapy.  Tamoxifen may reduce the risk of invasive breast cancer.  Risks and benefits of tamoxifen therapy should be discussed in this setting.

    Tamoxifen may be prescribed for women at high risk of breast cancer to reduce the incidence of developing breast cancer.  Risks and benefits of tamoxifen therapy should be discussed in this setting.

    Tamoxifen may also be prescribed for treatment of ovarian cancer.

    Note:  If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

     

    Side Effects:

    Important things to remember about the side effects of tamoxifen:

    Most people do not experience all of the side effects listed.

    Side effects are often predictable in terms of their onset and duration. 

    Side effects are almost always reversible and will go away after treatment is complete.

    There are many options to help minimize or prevent side effects.

    There is no relationship between the presence or severity of side effects and the effectiveness of the medication.

     

    The following side effects are common (occurring in greater than 30%) for patients taking tamoxifen:

    Hot flashes (see sexuality)

    Vaginal discharge (see sexuality)

    Swelling (fluid retention in feet, ankles, or hands)

    Loss of libido (particularly in men) (see sexuality)

     

    These side effects are less common side effects (occurring in about 10-29%) of patients receiving tamoxifen:

    Nausea

    Menstrual irregularities

    Vaginal bleeding

    Weight loss

    Mood changes (see anxiety and/or depression)

    A rare, but serious side effect of tamoxifen is blood clots, including deep vein thrombosis (DVT) and pulmonary embolus.  You should seek emergency help and notify your health care provider immediately if you develop sudden chest pain and shortness of breath.  Notify your health care provider within 24 hours if you notice that one leg is swollen, red, painful and/or warm to touch and the other is not.

     

     

     


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