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Anti-Estrogen Steroid Tamoxifen Breast Cancer Care TMX

Anti-Estrogen Steroid Tamoxifen Breast Cancer Care TMX

What is tamoxifen? Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. It is also used to lower a woman's chance of developing breast cancer if she has a...

  • Features & Specification

    What is tamoxifen?

    Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow.

    Tamoxifen is used to treat some types of breast cancer in men and women. It is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer).

    Tamoxifen may also be used for purposes not listed in this medication guide.

     

    How should I take tamoxifen?

    Tamoxifen can be taken with or without food.

    While using tamoxifen, you may need frequent blood tests.

    If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are taking tamoxifen.

    Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using this medicine.

    Use tamoxifen regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. You may need to keep using this medication for up to 5 years.

    Store at room temperature away from moisture, heat, or cold. Do not freeze.

     

    Before taking this medicine

    You should not use tamoxifen if you are allergic to it.

    You should not use tamoxifen to reduce your risk of breast cancer if you are also taking a blood thinner such as warfarin (Coumadin, Jantoven).

    Do not take tamoxifen if you are pregnant. It could harm the unborn baby. Avoid becoming pregnant while you are using this medicine, and for at least 2 months after your treatment ends.

    Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy while taking tamoxifen. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide, or intrauterine device/IUD).

    If you are taking tamoxifen to reduce your risk of breast cancer, you may need to take your first dose while you are having a menstrual period. You may also need to have a pregnancy test before you start taking tamoxifen, to make sure you are not pregnant. Follow your doctor's instructions.

    Taking tamoxifen may increase your risk of uterine cancer, stroke, or a blood clot in the lung, which can be fatal. Talk with your doctor about your specific risks in taking this medicine.

    To make sure tamoxifen is safe for you, tell your doctor if you have:

    a history of stroke or blood clot;

    liver disease;

    high cholesterol or triglycerides (a type of fat in the blood);

    a history of cataracts; or

    if you are receiving chemotherapy or radiation.

    It is not known whether tamoxifen passes into breast milk or if it could harm a nursing baby. This medicine may slow breast milk production. You should not breast-feed while taking tamoxifen.

     

    Tamoxifen side effects

    Get emergency medical help if you have signs of an allergic reaction to tamoxifen: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

    Tamoxifen can increase your risk of stroke or blood clots. Call your doctor at once if you have:

    signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

    signs of a blood clot in the lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or

    signs of a blood clot in your leg - pain, swelling, warmth, or redness in one or both legs.

    Also call your doctor at once if you have:

    blurred vision, tunnel vision, eye pain, or seeing halos around lights;

    unusual vaginal bleeding or discharge;

    changes in your menstrual periods;

    pain or pressure in your pelvic area;

    a new breast lump;

    liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

    high levels of calcium in your blood - vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, confusion, lack of energy, or tired feeling.

     

    Tamoxifen dosing information

    Usual Adult Dose for Breast Cancer:

    For the treatment of metastatic breast cancer in women and men:
    20 to 40 mg orally Dosages greater than 20 mg should be given in divided doses (morning and evening).
    For the treatment of women with Ductal Carcinoma in Situ, following breast surgery and radiation:
    20 mg orally daily for 5 years.
    To reduce the incidence of breast cancer in women at high risk for breast cancer:
    20 mg orally daily for 5 years.

     

    Usual Adult Dose for Breast Cancer - Adjuvant:

    For the treatment of node-positive breast cancer in postmenopausal women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation:
    10 mg orally 2 to 3 times a day for 5 years.

     

    Usual Adult Dose for Breast Cancer - Palliative:

    10 to 20 mg orally twice a day
    A beneficial response may not be evident for several months after initiation of therapy.

     

    Usual Pediatric Dose for McCune-Albright Syndrome:

    For use in girls age 2 to 10 years with McCune-Albright Syndrome and precocious puberty:
    20 mg once a day. The duration of treatment is up to 12 months.

     

    Usual Pediatric Dose for Precocious Puberty:

    For use in girls age 2 to 10 years with McCune-Albright Syndrome and precocious puberty:
    20 mg once a day. The duration of treatment is up to 12 months.

     

     


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