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MK 4305 Suvorexant for Insomnia Treatment

MK 4305 Suvorexant for Insomnia Treatment

Product introduction Best MK 4305 Peptides Whatsapp:+8618123940985 Skype:shucanlynn Emial:demi@chembj.com Other name:Suvorexant Keywords: suvorexant, MK-4305, orexin, respiration, obstructive sleep apnea, randomized trial

  • Features & Specification

    Product introduction

    Best MK 4305 Peptides

    Whatsapp:+8618123940985

    Skype:shucanlynn

    EmaIl:demi@chembj.com

    Sample:Available

    Price: Negotiable

    Customized blend :Available

    Standard: SGS,ISO9001,KOSHER

     

    Suvorexant (MK-4305)

    WhatsApp:+8618123940985
    Other name:Suvorexant
    Synonyms:5-Chloro-2-[(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl]-1,3-benzoxazole;MK 4305;(R)-(4-(5-chlorobenzo[d]oxazol-2-yl)-7-Methyl-1,4-diazepan-1-yl)(5-Methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)Methanone;Suvorexant;MK-4305 (Suvorexant);, [(7R)-4-(5-chloro-2-benzoxazolyl)hexahydro-7-Methyl-1H-1,4-diazepin-1-yl][5-Methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]-;Suvorexant (MK-4305);Suvorexant (with 4 ints.)
    CAS:1030377-33-3
    MF:C23H3ClN6O2
    MW:450.92072
    Melting point:153ºC
    density:1.41


    Keywords: suvorexant, MK-4305, orexin, respiration, obstructive sleep apnea, randomized trial


    Mechanism of Action:


    MK-4305 is a dual antagonist of orexin receptors OX1R and OX2R. It exerts its pharmacological effect by inhibiting binding of neuropeptides orexin A and B, also known as hypocretin 1 and 2, that are produced by neurons in the lateral hypothalamus. These neurons control the wake-promoting centers of the brain and are active during wakefulness, especially during motor activities, and stop firing during sleep. By inhibiting the reinforcement of arousal systems, suvorexant use causes a decrease in arousal and wakefulness, rather than having a direct sleep-promoting effect.

    Description:


    MK-4305 is a novel sedative hypnotic drug that is prescribed to promote sleep in patients with insomnia. It is a CNS depressant and blocks the binding of wake-promoting neuropeptides orexin A and orexin B to the two orexin receptors, thus, altering the signaling of orexin in the brain and suppressing the sleep-wake drive.
    Suvorexant is a central nervous system (CNS) depressant and can impair daytime wakefulness even when used as prescribed. Prescribers should monitor for somnolence and CNS depressant effects, but impairment can occur in the absence of symptoms, and may not be reliably detected by ordinary clinical exam. CNS depressant effects may persist in some patients for up to several days after discontinuing Suvorexant.

    Hypnotic drugs:


    MK-4305 is a new hypnotic drug developed by the US pharmaceutical giant Merck. Unlike other hypnotics, instead of being administrated on demand like general hypnotics (that is, they are taken only when needed), Merck's Suvorexant is a therapeutic drug, should be subject to long-term administration.
    Orexins usually transduces a variety of sobering messages for the human body, being the culprit leading to insomnia. Suvorexant can block Orexins to send messages, it is helpful to better sleep.
    Professor Andrew Krystal from the Center for Medical Research at Duke University said Merck's drug would become a new drug favored by patients.Darryle Schoepp, the head of neurology and ophthalmology at Merck, says MK-4305 is especially suitable for patients who have been unable to sleep all night and have received little benefit from existing medications.
    Suvorexant, sold under the trade name Belsomra, is a medication for the treatment of insomnia.It is effective for insomnia, at least for four weeks and as compared to a placebo.

     

    MK-4305 Dosage

    Dose range 10 mg to 100 mg, either as single dose or multiple daily dose over 14 days.

     

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    How to buy MK-4305? buy MK-4305 powder ?

    1.To contact us by our emailimage002.jpg(demi@chembj.com)inquiry system,or online skype(Skype: shucanlynn )customer service representative(CSR).Or image006.gifWhatsApp: +8618123940985
    2.To provide us your inquired quantity and address.
    3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
    4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
    5.Goods received and give comments.

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