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MK-1775 Adavosertib Treat Ovarian Cancer Powder

MK-1775 Adavosertib Treat Ovarian Cancer Powder

Product introduction Best MK1775 Peptides Whatsapp:+8618123940985 Skype:shucanlynn Emial:demi@chembj.com Sample:Available Price: Negotiable Customized blend :Available Standard: SGS,ISO9001,KOSHER Product Name MK-1775 Alias MK1775, MK 1775 CAS 955365-80-7 MF C27H32N8O2 MW 500.59538 Purity 99.50%...

  • Features & Specification

    Product introduction

    Best MK1775 Peptides

    Whatsapp:+86 18123940985

    Skype:shucanlynn

    Email:demi@chembj.com

    Sample:Available

    Alias       MK1775, MK 1775

    CAS       955365-80-7

    MF  C27H32N8O2

    MW 500.59538

    Purity     99.50%

    Grade    Pharmaceutical Grade

    Appearance  yellow powder

    Standard       USP

    Stock     Mass Stock

    Storage  store at 0-5 ℃

    Packing Methods designed disguised packing ways, 100% pass custom guarantee

    Delivery time within 18 hours after payment confirmed

    Payment T/T, Western Union,Money Gram , Bitcoin

     

    What is MK-1775? 

    MK-1775 is an inhibitor of the checkpoint kinase Wee1 (IC50 = 5.2 nM).1 It has been shown to inhibit the phosphorylation of Cdc2 at tryosine-15, which abrogates the G2 DNA damage checkpoint.1 In p53-deficient tumors that rely solely on the G2 checkpoint upon DNA damage, MK-1775, in combination with DNA-damaging chemotherapeutic agents, is reported to induce apoptosis in vitro and potentiate the inhibition of tumor growth in vivo.

     

    MK-1775 Dosage :20 mg twice daily. 


    MK-1775 Application: 


    Treatment with MK-1775 resulted in inhibition of Wee1 kinase and decreased the inhibitory phosphorylation of its substrate Cdc2. Compared to control and gemcitabine-treated tumors, MK-1775 eliminates checkpoint block when administered with gemcitabine to promote mitotic entry and promote tumor cell death. MK-1775 monotherapy did not induce tumor regression. However, the combination of gemcitabine with MK-1775 produced potent anti-tumor activity and significantly enhanced tumor regression (4.01 fold) compared to gemcitabine treatment in p53-deficient tumors. The re-growth curve of the tumor drawn after the drug treatment period shows that the combination therapy is longer than gemcitabine. None of the drugs produced tumor regression in p53 wild type xenografts. 


    MK-1775 inhibits Wee1 kinase in an ATP-competitive manner. Compared with Wee1, the inhibitory effect of MK-1775 was 2 to 3 times lower than that of Yes, and the IC50 was 14 nM. The inhibitory effect on other 7 kinases was 10 times lower, and the inhibition rate was > 80% at 1 μM. The selectivity was higher than humans. 100-fold Myt 1 is another kinase (Thr14) that inhibits cyclin-dependent kinase 1 (CDC2) by phosphorylation at the alternative site.

     

    Note :

    MK1775 in 0.5% methylcellulose is a suspension or emulsion, and it is ok to treat mice orally. It is recommended to dissolve methylcellulose in saline. It will take some time to dissolve methylcellulose, and you can vortex it for a while. The MK1775 methylcellulose solution can be stored at 4°C for a week.


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    Whatsapp:+86 18123940985

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