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MK-1439 NNRT New HIV Med Doravirine

MK-1439 NNRT New HIV Med Doravirine

Product introduction Best MK-1439 Peptides Whatsapp:+8618123940985 Skype:shucanlynn Emial:demi@chembj.com CAS 1338225-97-0 Sample:Available Price: Negotiable Customized blend :Available Standard: SGS,ISO9001,KOSHER Name:MK-1439 Other name:Doravirine MF:C17H11ClF3N5O3 MW:425.7491496...

  • Features & Specification

    Product introduction

    Best MK-1439 Peptides

    Whatsapp:+86 18123940985

    Skype:shucanlynn

    Email:demi@chembj.com

    CAS 1338225-97-0

    Sample:Available

    Price: Negotiable

    Customized blend :Available

    Standard: SGS,ISO9001,KOSHER 

    Name:MK-1439

    image002.jpg


    Other name:Doravirine
    MF:C17H11ClF3N5O3
    MW:425.7491496
    CAS:1338225-97-0

     

    MK-1439 Dosage


    Adult Dose: One tablet once a day. Each tablet contains 100mg doravirine + 300mg tenofovir disoproxil fumarate + 300mg lamivudine. 


    MK-1439 is an experimental HIV medication. It contains three different types of HIV drugs: one non-nucleoside reverse transcriptase inhibitor (NNRTI) and two nucleoside reverse transcriptase inhibitors (NRTIs). It is currently in Phase III clinical trials. 


    MK-1439 is a single-tablet regimen containing generic versions of two currently approved HIV medications (tenofovir disoproxil fumarate and lamivudine) and one experimental HIV medication (doravirine). 


    MK-1439 Description 

    Doravirine (MK-1439) is a non-nucleoside reverse transcriptase inhibitor under development . for use in the treatment of HIV/AIDS. Doravirine demonstrated robust antiviral activity and good tolerability in a small clinical study of 7-day monotherapy reported at the 20th Conference on Retroviruses and Opportunistic Infections in March 2013. Doravirine appeared safe and generally well-tolerated with most adverse events being mild-to-moderate. 

     

    Brief Summary: 

    To establish a new treatment option for treatment-naïve participants with HIV-1, the efficacy and safety of doravirine will be determined relative to a protease inhibitor (PI). Participants will receive double-blind treatment during the 96-week Base Study. Eligible participants in either of the Base Study groups will continue to receive the doravirine-containing regimen open label for an additional 96 weeks in the Extension Study. The primary hypothesis is that doravirine 100 mg once a day (q.d.) is non-inferior to darunavir/ritonavir (800 mg/100 mg) q.d., each in combination with TRUVADA or EPZICOM/KIVEXA, as assessed by the proportion of participants with HIV-1 ribonucleic acid (RNA) <50 copies/mL at Week 48. If non-inferiority is established, then the superiority of doravirine 100 mg q.d. compared to darunavir/ ritonavir (800 mg/100 mg) q.d. will be assessed.

     

    SARMs List

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    S4 (Andarine)
    SR9009 (Stenabolic)
    SR9011
    YK11
    GW501516(GSK-516)
    AICAR
    S-23
    LGD-3303
    GW-0742
    MK-1775

     

    Please feel free contact me

    Whatsapp:+86 18123940985

    Skype:shucanlynn

    Email:demi@chembj.com

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