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GSK2118436 Tafinlar Dabrafenib for Melanoma Treatment

Product introduction Best Dabrafenib Tafinlar Peptides Whatsapp:+8618123940985 Skype:shucanlynn Emial:demi@chembj.com Sample:Available Price: Negotiable Customized blend :Available Standard: SGS,ISO9001,KOSHER Product name: Dabrafenib Whatsapp:+8618123940985 Other name:GSK2118436,Tafinlar...

  • Features & Specification

    Product introduction

    Best Dabrafenib Tafinlar Peptides

    Whatsapp:+86 18123940985

    Skype:shucanlynn

    Email:demi@chembj.com

    Sample:Available

    Price: Negotiable

    Customized blend :Available

    Standard: SGS,ISO9001,KOSHER 

     

    Product name: Dabrafenib

    Whatsapp:+8618123940985

    image002.jpg

    Other name:GSK2118436,Tafinlar

    Synonyms:Dabrafenib;N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;Dabrafenib free base(GSK2118436A);Dabrafenib(GSK2118436);GSK2118436A;Dabrafenib (GSK2118436);Dabrafenib KB-57246;Debrafenib API

    CAS NO 1195765-45-7

    MF  C23H20F3N5O2S2

    MW 519.5624096

    EINECS 200-366-3

    Appearance  White to slightly yellowish-white crystalline

    Assay     99%min

    Storage  Shading, confined preservation

    Delivery EMS, DHL, TNT, FedEx, UPS

    Delivery time within 24 hours upon receipt of payment

    Product Category Raf B protein kinase inhibitor;inhibitor;MAPK;Inhibitors

     

    What is Dabrafenib ? 


    Dabrafenib, which also goes under the brand name Tafinlar, is used to treat melanoma skin cancer, particularly if it has spread or is not responding to treatment.


    The drug is a cancer-growth blocker that sends signals to stop tumour cells growing and dividing.

    Dabrafenib is only effective in patients with a change in a gene known as BRAF as it works on its protein.

    Around 50 per cent of people with melanoma have a change in the BRAF gene.


    Dabrafenib is taken as 50 mg twice a day. Dabrafenib is often consumed with another cancer drug, known as trametinib.

     

    Dabrafenib Side Effects

    Dabrafenib can cause fevers, high blood pressure and rashes, as well as end-stage kidney disease and liver complications.

     

    Other Small molecular API:

    AZD9291

    1421373-65-0

    E7080

    417716-92-8

    Afatinib diMaleate

    439081-18-2

    XL184 S-MALATE

    1140909-48-3

    Crizotinib

    877399-52-5

    Axitinib

    319460-85-0

    WZ4002

    1213269-23-8

    Vandetanib

    443913-73-3

    Sunitinib

    557795-19-4

    Regorafenib

    755037-03-7

    Imatinib

    152459-95-5

     

    Dosage 

    Patients were randomized to receive trametinib 2 mg orally once daily in combination with dabrafenib 150 mg orally twice daily (n=54), trametinib 1 mg orally once daily in combination with dabrafenib 150 mg orally twice daily (n=54), or single-agent dabrafenib 150 mg orally twice daily (n=54). Of the 162 patients enrolled, 57% were male, the median age was 53 years, all had baseline ECOG PS of 0 or 1, 67% had M1c disease, and 81% had not received prior anticancer therapy for unresectable or metastatic disease. All patients had tumor tissue with mutations in BRAF V600E (85%) or V600K (15%) on local or centralized testing. 


    The recommended dose and schedule for trametinib and dabrafenib when used in combination is trametinib 2 mg orally once daily with dabrafenib 150 mg orally twice daily continued until disease progression or unacceptable toxicity occurs. Trametinib and dabrafenib should be taken at least one hour before or two hours after a meal. The once daily dose of trametinib can be taken at the same time as either dose of dabrafenib.

     

    Please feel free contact me

    Whatsapp:+86 18123940985

    Skype:shucanlynn

    Email:demi@chembj.com

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