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Etoricoxib Arcoxia MK 663 for Osteoarthritis

Etoricoxib Arcoxia MK 663 for Osteoarthritis

Product introduction Best MK-663 Etoricoxib Peptides Whatsapp:+861 8123940985 Skype:shucanlynn Emial:demi@chembj.com Sample:Available Price: Negotiable Customized blend :Available Standard: SGS,ISO9001,KOSHER Resend:Resend Policy Payment Method: Banktransfer,MoneyGram,Western Union,Bitcoin Free...

  • Features & Specification

    Product introduction

    Best MK-663 Etoricoxib Peptides

    Whatsapp:+8618123940985

    Skype:shucanlynn

    Emial:demi@chembj.com

    Sample:Available

    Price: Negotiable

    Customized blend :Available

    Standard: SGS,ISO9001,KOSHER

    Resend:Resend Policy

    Payment Method: Banktransfer,MoneyGram,Western Union,Bitcoin

    Free Sample: Yes

    Delivery: DHL,FEDEX,EMS,TNT And So On 

    Name:Etoricoxib

    Other name:Etoricoxib,MK-663

    Synonyms: 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine;ETORICOXIB;5-Chloro-6'-methyl-3-[4-(methylsulfonyl) phenyl]-2,3'-bipyridine;Arcoxia;5-chloro-3-(4-Methanesulfonylphenyl)-2-(6-Methylpyridin-3-yl)pyridine;Etoricoxib-D4;2,3'-Bipyridine, 5-chloro-6'-Methyl-3-[4-(Methylsulfonyl)phenyl]-;Algix

    CAS: 202409-33-4

    MF: C18H15ClN2O2S

    MW: 358.84

     

    What is Etoricoxib? 

    Etoricoxib is a non-steroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic effects in animal models. It is an orally active, selective cyclooxygenase-2 inhibitor in the clinical dose range or higher. It has been confirmed that there are two subtypes of cyclooxygenase: cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). 

    COX-1 is involved in prostaglandin-mediated normal physiological functions such as gastric cell protection and platelet aggregation. Non-selective non-steroidal anti-inflammatory drugs inhibit the production of COX-1 and therefore can cause gastric mucosal damage and reduced platelet aggregation. COX-2 is mainly involved in the production of prostaglandins, which can cause pain, inflammation and fever. 

    Etoricoxib is a selective COX-2 inhibitor that reduces these signs and symptoms and reduces gastrointestinal side effects without affecting platelet function.

     

    Etoricoxib Dosage 

    60 mg once-daily.

     

    Product Information: 

    1, Treatment of OA: This product is equivalent to celecoxib, ibuprofen, and high-dose diclofenac and naproxen efficacy similar. 

    2, acute gouty arthritis: This product 120mg / d, can quickly and effectively relieve pain, compared with the treatment of gouty arthritis, the gold standard drug indomethacin is also effective, and rely on Coxixine tolerance is better, The incidence of drug-related adverse events is lower than that of indomethacin. 

    3. Ankylosing spondylitis: Reliance on COX and naproxen 2 times a day is similar, relying on COX is more effective in improving secondary endpoints such as night pain, inflammation, function, and flexibility. 

    4. Rheumatoid arthritis: Large-scale, controlled clinical trials have shown that relying on coxixima once per day is superior to naproxen twice a day and patients are well tolerated. 

    5. Osteoarthritis: This product is effective once/day with celecoxib once/day and ibuprofen 3 times/day; and once/day with high-dose diclofenac (3 times/day) and naphthalene Prussian (3 times / day) similar efficacy. 

    6. Post-dental surgery pain: Compared to acetaminophen/codeine and oxycodone/acetaminophen, taking etoricoxib once daily had better pain relief. 

    7. Chronic low back pain: comparing the efficacy of this product with placebo for chronic low back pain for 12 weeks, the clinical efficacy of this product is significantly better than placebo, markedly effective in 1 week, effective in 4 weeks, and lasting more than 3% Months. 

    8, Control of postoperative thyroid pain in patients with thyroid surgery: 1 hour before surgery, oral administration of coxixib, after 6 ~ 12 h after oral administration of phenol oxycodone decreased.

     

    Etoricoxib Usage And Synthesis 

    Chemical Properties Off-White Powder

    Usage A specific inhibitor of COX-2 .

    Usage anti-inflammatory, analgesic;cyclooxygenase inhibitor

    Usage For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout.

    Usage Labeled Etoricoxib, intended for use as an internal standard for the quantification of Etoricoxib by GC- or LC-mass spectrometry.

     

    SARMs List

    MK-2866 (Ostarine)
    RAD-140 (Testolone)
    MK-677 (Ibutamoren; Nutrobal)
    LGD-4033 (Ligandrol; Anabolicum)
    S4 (Andarine)
    SR9009 (Stenabolic)
    SR9011
    YK11
    GW501516(GSK-516)
    AICAR
    S-23
    LGD-3303
    GW-0742
    MK-1775


    Please feel free contact me

    Whatsapp:+8618123940985

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