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androcur Powder Cyproterone Acetate

androcur Powder Cyproterone Acetate

Cyproterone Acetate Powder Quick Details: Cyproterone Acetate Powder CAS No.: 427-51-0 EINECS: 207-048-3 MF: C24H29ClO4 MW: 416.94 MP: 200-201°C Storage temp.: 2-8°C Purity: 99% min Appearance: White Crystalline Solid Usage: The free alcohol is an anti-androgen; the acetate is both an...

  • Features & Specification

    Cyproterone Acetate Powder Quick Details:
    Cyproterone Acetate Powder
    CAS No.: 427-51-0
    EINECS: 207-048-3
    MF: C24H29ClO4
    MW: 416.94
    MP: 200-201°C
    Storage temp.: 2-8°C
    Purity: 99% min
    Appearance: White Crystalline Solid
    Usage: The free alcohol is an anti-androgen; the acetate is both an anti-androgen and a progestogen. Combined with estrogen it is used in the treatment of acne.

     

    Cyproterone Acetate Powder Description:
    Cyproterone acetate, sometimes abbreviated as CPA, and sold under brand names such as Androcur and Cyprostat, is a synthetic steroidal antiandrogen drug with additional progestogen and antigonadotropic properties.Its primary action is to suppress the activity of the androgen hormones such as testosterone and its more potent metabolite dihydrotestosterone (DHT) in the body, effects which it mediates via competitive antagonism of the androgen receptor and inhibition of enzymes in the androgen biosynthesis pathway.

     

    Cyproterone Acetate Powder Function:
    Reduce male paraphilic sexual desire; not operation of prostate cancer; severe masculinization of female signs: like the very severe hirsutism, androgen-dependent severe hair loss, ultimately leading to the bald ( severe androgenetic alopecia ), often accompanied by severe acne and / or seborrheic.

     

    Cyproterone Acetate Powder Application:
    Cyproterone acetate has antagonistic properties towards the androgen receptor with an IC50 value of 7.1 nM. It can however, also act as a partial agonist of AR at an EC50 of 4.0 μM. In the presence of 10 nM testos terone, low concentrations of Cyproterone acetate inhibits T-stimulated transcription of 3XHRE-LUC, but at higher concentrations, transcription is stimulated.Cyproterone Acetate is also a hepatomitogen and tumor promoter and induces apoptosis in hepatocytes.

     

    Cyproterone Acetate Powder Certificate of Analysis:

    Items

    Specifications

    Results

    Appearance

    White or almost white crystalline powder

    Almost white crystalline powder

    Melting point

    About 210℃

    210℃

    Specific optical rotation

    +152°~+157°

    +155.1°

    Identification

    Complies by IR

    Conforms

    Related substances

    Impurity F

    Not more than 0.4%

    Undetected

    Impurity E

    Not more than 0.2%

    0.04%

    Impurity B

    Not more than 0.15%

    Undetected

    Impurity G

    Not more than 0.15%

    Undetected

    Impurity C

    Not more than 0.15%

    Undetected

    Any other impurity

    Not more than 0.10%

    0.07%

    Total impurities

    Not more than 0.5%

    0.16%

    Loss on drying

    Not more than 0.5%

    0.20%

    Sulphated ash

    Not more than 0.1%

    0.06%

    Assay

    Contains 97.0% to 103.0% of C24H29ClO4

    99.80%

    Conclusion

    The goods conforms to EP8.0

    图片1_副本.jpg

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