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Regional Injectable Mepivacaine Hydrochloride Powder

Regional Injectable Mepivacaine Hydrochloride Powder

Regional injectable Mepivacaine hydrochloride powder Mepivacaine hydrochloride main details What is Mepivacaine hydrochloride? Mepivacaine hydrochloride is a local anesthetic that is chemically related to Bupivacaine but pharmacologically related to Lidocaine. It is indicated for infiltration,...

  • Features & Specification

    Regional injectable Mepivacaine hydrochloride powder

    Mepivacaine hydrochloride main details

    Product name

    Mepivacaine   hydrochloride

    CAS NO.

    1722-62-9

    Purity

    99%

    Standard

    USP

    Grade

    Pharmaceutical grade

    Usage

    1)   Amide group Local anesthetic

    2)   Regional   injection, not intravenous injection.

     

    What is Mepivacaine hydrochloride?

    Mepivacaine hydrochloride is a local anesthetic that is chemically related to Bupivacaine but pharmacologically related to Lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route.

     

    How does Mepivacaine hydrochloride work?

    Mepivacaine Hydrochloride is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties. In injectable form, mepivacaine hydrochloride acts by binding to specific membrane sodium ion channels in the neuronal cell membranes, thereby inhibiting sodiuminflux. So this leads to a blockage of nerve impulse conduction and results in a loss of sensation. It does not ordinarily produce irritation or tissue damage.

     

    Mepivacaine hydrochloride Dosage

    For local infiltration of anesthesia: 0.25% to 0.5%,

    For nerve block anesthesia: 1.0% to 2.0%,

    For epidural block anesthesia : 1.5% to 2.0%.

    Dosage: 1 to 3 doses per adult treatment limit. Depending on the scope of anesthesia and the use of anesthesia technology. Injection speed: should not exceed 1ml per minute.

     

    Mepivacaine hydrochloride Effects

    Mepivacaine hydrochloride stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses, thereby effecting local anesthesia. 
    Mepivacaine hydrochloride is rapidly metabolized, with only a small percentage of the anesthetic (5 to 10 percent) being excreted unchanged in the urine. Mepivacaine because of its amide structure, is not detoxified by the circulating plasma esterases. The liver is the principal site of metabolism, with over 50 percent of the administered dose being excreted into the bile as metabolites. Most of the metabolized Mepivacaine is probably resorbed in the intestine and then excreted into the urine since only a small percentage is found in the feces. 

    The principal route of excretion is via the kidney. Most of the anesthetic and its metabolites are eliminated within 30 hours. It has been shown that hydroxylation and N-demethylation, which are detoxification reactions, play important roles in the metabolism of the anesthetic. Three metabolites of Mepivacaine have been identified from adult humans: two phenols, which are excreted almost exclusively as their glucuronide conjugates, and the N-demethylated compound (2´,6´ - pipecoloxylidide).

     

    Buy Mepivacaine hydrochloride

    MOQ: 10 grams

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