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Anti Analgesic Powder Mepivacaine Hydrochloride

Anti Analgesic Powder Mepivacaine Hydrochloride

Abstract Mepivacaine Hydrochloride, a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride. A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve...

  • Features & Specification

    Abstract
    Mepivacaine Hydrochloride, a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride.
    A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route.


    Pharmacodynamics
    Mepivicaine is a local anesthetic of the amide type. Mepivicaine as a reasonably rapid onset and medium duration and is known by the proprietary names as Carbocaine and Polocaine. Mepivicaine is used in local infiltration and regional anesthesia. Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems. At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal.

     

    COA

    Product   name

    Mepivacaine   HCl

    Appearance

    White   crystalline powder

    Assay   (C13H20N2O2·HCl)

    99.0%   to 101.0%

    99.50%

    Melting   point

    153~158ºC

    156.5~157.0ºC

    Heavy   metals

    ≤20ppm

    <5ppm

    Acidity

    ≤0.02N   NaOH 0.5ml

    0.3ml

    Chromatographic   purity

    Secondary   spots≤0.5%,sum≤1.0%

    Conforms

    Loss on   drying

    ≤1.0%

    0.06%

    Residue   on ignition

    ≤0.15%

    0.03%

    Bacterial   endotoxins

    ≤0.6EU/mg

    <0.6EU/mg

      

    DESCRIPTION

    Mepivacaine Hydrochloride, a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride with the following structural formula:

    image002.gif


    It is a white, crystalline, odorless powder soluble in water, but very resistant to both acid and alkaline hydrolysis.Levonordefrin, a sympathomimetic amine used as a vasoconstrictor in local anesthetic solution, is (-)-image004.gif-(1-Aminoethyl)-3, 4-dihydroxybenzyl alcohol with the following structural formula:

    image006.gif

    It is a white or buff colored crystalline solid, freely soluble in aqueous solutions of mineral acids, but practically insoluble in water;


    DENTAL CARTRIDGES MAY NOT BE AUTOCLAVED.

    Mepivacaine hydrochloride injection 3% and Mepivacaine hydrochloride 2% with levonordefrin 1:20,000 injection are sterile solutions for injection.

     

    COMPOSITION 

    Each mL contains:

    CARTRIDGE

    2%

    3%

      Mepivacaine   Hydrochloride

    20 mg

    30 mg

      Levonordefrin

    0.05 mg

    -

      Sodium   Chloride

    4 mg

    6 mg

      Potassium   metabisulfite

    1.2 mg

    -

      Edetate   disodium

    0.25 mg

    -

      Sodium   Hydroxide q.s. ad pH; Hydrochloric Acid

    0.5 mg

    -

      Water   For Injection, qs. ad.

    1 mL

    1 mL

      The   pH of the 2% cartridge solution is adjusted between 3.3 and 5.5 with NaOH.

      The   pH of the 3% cartridge solution is adjusted between 4.5 and 6.8 with NaOH.

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