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Topical Anesthetic Lidocaine with Quick Numb

Topical Anesthetic Lidocaine with Quick Numb

What is lidocaine-injection (local), and how does it work (mechanism of action)? Lidocaine injection is a local anesthetic. This means that it reduces sensation or pain in the area of the body where it is injected and does not affect other areas. It is similar to bupivacaine (Marcaine),...

  • Features & Specification

    What is lidocaine-injection (local), and how does it work (mechanism of action)?

    Lidocaine injection is a local anesthetic. This means that it reduces sensation or pain in the area of the body where it is injected and does not affect other areas. It is similar to bupivacaine (Marcaine), articaine (Zorcaine), and Mepivacaine (Carbocaine). These drugs reduce sensation or pain by blocking nerve impulses that send pain sensations to the brain. Lidocaine starts working within 90 seconds and the effects last about 20 minutes.

     

    Applications:

    Topical lidocaine has been shown in some patients to relieve the pain of postherpetic neuralgia (a complication of shingles), though not enough study evidence exists to recommend it as a first-line treatment.lidocaine also has uses as a temporary fix for tinnitus. Although not completely curing the disorder, it has been shown to reduce the effects by around two-thirds.

    Lidocaine is also the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated.

    Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.

    Inhaled lidocaine can be used as an antitussive (cough suppressor) acting peripherally to reduce the cough reflex. This application can be implemented as a safety and comfort measure for patients who have to be intubated, as it reduces the incidence of coughing and any tracheal damage it might cause when emerging from anesthesia.

    Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge.

     

    Analysis Report

    TEST ITEMS

    SPECIFICATION

    RESULTS

    Description

    White or Almost White Crystalline Powder

    white powder

    Identification

    A.B.

    Positive

    Assay

    97.0~103.0%

    99.20%

    Specific Rotation

    +101°~+105°

    +102.6°

    Loss On Drying

    1.0%max

    0.28%

    Melting Point

    153~157°C

    153.0~155.0°C

    Organic Volatile Impurities

    meets the requirement.

    Conforms

    Related Substances

    meets the requirement.

    Conforms

    Residual Solvents

    meets the requirement.

    Conforms

    Particle Size

    100% ≤ 20 microns

    Conforms

    Conclusion

    The specification conform with USP30 standard

     

    What are the side effects of lidocaine-injection (local)?

    Common side effects of lidocaine are:

    injection site pain,

    feeling lightheaded,

    euphoria,

    shaking,

    low blood pressure,

    drowsiness,

    confusion,

    weakness,

    blurry or double vision, and

    dizziness.

    Other important side effects which may be serious include:

    seizures,

    abnormal heart beats,

    slow heart beat,

    heart block,

    severe allergic reactions,

    respiratory arrest, and

    coma.


    What is the dosage for lidocaine-injection (local)?

    Dosing varies considerably depending on the use. Total recommended doses range from 20 mg to 300 mg.


    Which drugs or supplements interact with lidocaine-injection (local)?

    Administering lidocaine solutions containing epinephrine or norepinephrine (which are added to prolong the action of the lidocaine) to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe and prolonged high blood pressure. Such combinations should be avoided. A similar reaction may occur with drugs used to increase blood pressure

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