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Pain Killer Tetracaine with Discreet Packing

Pain Killer Tetracaine with Discreet Packing

What is tetracaine ophthalmic drops, and how does it work (mechanism of action)? Tetracaine is a topical local anesthetic for the eyes. Tetracaine works by interfering with entry of sodium ions into nerve cells. This reduces the ability of nerves to generate an impulse and send pain sensations....

  • Features & Specification

    What is tetracaine ophthalmic drops, and how does it work (mechanism of action)?

    Tetracaine is a topical local anesthetic for the eyes. Tetracaine works by interfering with entry of sodium ions into nerve cells. This reduces the ability of nerves to generate an impulse and send pain sensations.

     

    Tetracaine Quick Details:

    Product Name: Tetracaine
    Synonym: Anetain, Amethocaine, Pontocaine,Ametop,Dicaine
    CAS: 94-24-6
    MF: C15H24N2O2
    MW: 264.36
    EINECS: 202-316-6
    Assay: 99%
    Quality Standards: Enterprise Standard/Pharma Grade
    Appearance: White powder
    Package:25kg/Drum

    Usage: Tetracaine is a topical local anesthetic for the eyes. Tetracaine works by interfering with entry of sodium ions into nerve cells. This reduces the ability of nerves to generate an impulse and send pain sensations.

     

    Tetracaine COA:

    Test Items

    Specification

    Test Results

    Appearance

    Fine, white, crystalline, odorless powder

    confirm

    Identification

    ABC in Pass

    confirm

    Solubility

    Very soluble in water, soluble in Alcohol;
      insoluble in Ether and Benzene

    confirm

    USP Reference standards

    USP Tetracaine Hydrochloride RS.
      USP Endotoxin RS.

    confirm

    Melting point

    145~150 degree

    146.0~147.5 degree

    Chromatographic purity

    In Pass

    confirm

    Related substance

    Not more than the reference solution 0.05%

    confirm

    Heavy metals

    ≤10ppm

    confirm

    PH

    4.5-6.5

    5.8

    Residue on ignition

    ≤0.10%

    0.05%

    Loss on Drying

    ≤ 0.5%

    0.19%

    Assay

    98.0 -101.0%

    100.1%

    Conclusion

    Confirms USP 32

     

    Tetracaine Application

    (1).In biomedical research, tetracaine is used to alter the function of the calcium release pathway (Lannottine receptor), which controls the release of calcium from intracellular stores. Dicaine is an allosteric blocker for channel function. At low concentrations, tetracaine causes initial inhibition of spontaneous calcium release events, whereas at high concentrations, tetracaine is completely released.

    (2).Dinkaine is T in Tac, 5 to 12% tetracaine, 5M (countless), half (0.5 ‰) or 0.05% (1 in 2000), 4% or 10% of the salt used for ENT surgery Acid salts, and emergency departments that require rapid surface numbness, especially when children are injured in the eyes, ears or other sensitive parts.

    (3).Tetracaine is synthesized from 4-butylaminobenzoic acid. The esterification reaction is carried out by acid catalysis to form ethyl ester. The base-catalyzed transesterification is achieved by boiling ethyl 4-butylaminobenzoic acid with an excess of 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

     

    Tetracaine Dosing 

    Spinal   Anesthesia

    High,   median, low & saddle: 0.2%-0.3% solution

    For perineum: 5 mg/dose
    For lower extremities: 10 mg/dose
    For saddle block: 2-5 mg/dose
    Prolonged (2-3 hours): 1% solution
    For spinal: 1% solution diluted 1:1 in CSF, administered at 1 mL per 5   seconds
    Doses of >15 mg are rarely required, and should only be used in   exceptional cases

    Ophthalmic

    Short   term anesthesia: 1-2 gtt into affected eye just prior to evaluation

    Minor surgical procedure: 1-2 gtt into   affected eye q5-10min
    Prolonged surgical procedure: 1-2 gtt into affected eye q5-10min; not to   exceed 5 doses


    What are the side effects of tetracaine ophthalmic drops?

    Side effects of tetracaine are:

    drowsiness,

    stinging eyes,

    burning eyes,

    redness, and

    hypersensitivity reactions.

     

    What is the dosage for tetracaine ophthalmic drops?

    For tonometry and other short procedures: Instill 1 to 2 drops in the eye(s) just prior to evaluation.

    For minor surgical procedures, such as foreign body or suture removal: Instill 1 to 2 drops in the eye(s) every 5 to 10 minutes for 1 to 3 instillations.

    For prolonged anesthesia, such as cataract extraction: Instill 1 to 2 drops in the eye(s) every 5 to 10 minutes for 3 to 5 doses.

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