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Anthelmintics Powder Levamisole with 150mg Dosage

Anthelmintics Powder Levamisole with 150mg Dosage

Name : Levamisole CAS number : 14769-73-4 Weight Average: 204.291 Monoisotopic: 204.072119084 Chemical Formula : C11H12N2S Absorption : Levamisole is rapidly absorbed (2 hours) from the gastrointestinal tract. Protein binding : 20-25% Metabolism : Primarily hepatic (extensive) with both active...

  • Features & Specification

    Name: Levamisole

    CAS number: 14769-73-4

    Weight Average: 204.291 
    Monoisotopic: 204.072119084

    Chemical Formula: C11H12N2S

    Absorption: Levamisole is rapidly absorbed (2 hours) from the gastrointestinal tract.

    Protein binding: 20-25%

    Metabolism: Primarily hepatic (extensive) with both active and inactive metabolites.

    Half life: 4.4-5.6 hours (biphasic)

    Toxicity: LD50 = 40 mg/kg (Pigs, subcutaneous); LD50 = 180 mg/kg (rat, oral)

    Affected organisms: Humans and other mammals

      

    Description:

    An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6). Levamisole was withdrawn from the US and Canadian markets in 2000 and 2003, respectively, due to the risk of serious side effects and the availability of more effective replacement medications. [Wikipedia] 

     

    Indication:

    For adjuvant treatment in combination with fluorouracil after surgical resection in patients with Dukes' stage C colon cancer. Also used to treat malignant melanoma and head/neck cancer. Levamisole was originally used as an antihelminthic to treat worm infestations in both humans and animals. 

     

    Pharmacodynamics:

    Levamisole is a synthetic imidazothiazole derivative that has been widely used in treatment of worm infestations in both humans and animals. As an anthelmintic, it probably works by targeting the nematode nicotinergic acetylcholine receptor. As an immunomodulator, it appears that Levamisole is an immunostimulant which has been shown to increase NK cells and activated T-cells in patients receiving this adjuvantly along with 5FU for Stage III colon cancer. 

     

    Mechanism of action:

    The mechanism of action of levamisole as an antiparasitic agent appears to be tied to its agnositic activity towards the L-subtype nicotinic acetylcholine receptors in nematode muscles. This agonistic action reduces the capacity of the males to control their reproductive muscles and limits their ability to copulate. The mechanism of action of Levamisole as an anticancer drug in combination with fluorouracil is unknown. The effects of levamisole on the immune system are complex. The drug appears to restore depressed immune function rather than to stimulate response to above-normal levels. Levamisole can stimulate formation of antibodies to various antigens, enhance T-cell responses by stimulating T-cell activation and proliferation, potentiate monocyte and macrophage functions including phagocytosis and chemotaxis, and increase neutrophil mobility, adherence, and chemotaxis. 

     

    HOW TO USE: 

    Take this medication exactly as prescribed. Do not increase your dose or take it more often. Your condition will not improve faster by taking more medication, but side effects will be increased. This medication may be taken with food or milk to minimize nausea. 

     

    STORAGE:

    Store at room temperature and keep away from moisture and sunlight. Do not store in the bathroom.

     

    SIDE EFFECTS: 

    This medication causes nausea, vomiting, diarrhea, mouth sores, loss of appetite, stomach pain, change in taste and smell, muscle aches, fatigue, dizziness, headache and skin rash. Notify your doctor if these symptoms become bothersome. Notify your doctor if you develop: flu-like symptoms (fever, chills, weakness, sore throat). If you notice other effects not listed above, contact your doctor or pharmacist.

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