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ARIMIDEX tablets for oral administration contain 1 mg of anastrozole, a non-steroidal aromatase inhibitor.ARIMIDEX has moderate aqueous solubility (0.5 mg/mL at 25°C); solubility is independent of pH in the physiological range. Anastrozole is freely soluble in methanol, acetone, ethanol, and...
ARIMIDEX, a non-steroidal aromatase inhibitor.it has moderate aqueous solubility (0.5 mg/mL at 25°C); Anastrozole is freely soluble in methanol, acetone, ethanol, and tetrahydrofuran, and very soluble in acetonitrile.
Recipe(200ml @5mg/ml)
1 gram of pure powder
19.9 ml’s PEG 300
179.1
ml’s of 190 Proof Grain Alcohol
INDICATIONS
Adjuvant Treatment
it is indicated for adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer.
First-Line Treatment
it is indicated for the first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer.
Second-Line Treatment
it is indicated for the treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy. Patients with ER-negative disease and patients who did not respond to previous tamoxifen therapy rarely responded to ARIMIDEX.
Recommended Dose
The dose is one 1 mg tablet taken once a day. For patients with advanced breast cancer, it should be continued until tumor progression. it can be taken with or without food.
For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. In the ATAC trial, it was administered for five years.
No dosage adjustment is necessary for patients with renal impairment or for elderly patients [see Use In Specific Populations].
Patients With Hepatic Impairment
No changes in dose are recommended for patients with mild-to-moderate hepatic impairment. it has not been studied in patients with severe hepatic impairment.
Dosage Forms And Strengths
The tablets are white, biconvex, film-coated containing 1 mg of anastrozole. The tablets are impressed on one side with a logo consisting of a letter “A” (upper case) with an arrowhead attached to the foot of the extended right leg of the “A” and on the reverse with the tablet strength marking “Adx 1”.
Storage
Store at controlled room temperature, 20-25°C (68-77°F).
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